Going beyond symptoms - Treating mental disorders by using data originating in deep brain regions
Prism will be used by Healthcare Providers to enhance standard of care clinical outcomes.
Prism uses an Amygdala-fMRI-guided model for processing EEG signals. Prism uses several electrodes EEG-signal to produce a real time Amygdala-derived-EFP biomarker signal to train patients in downregulating the Amygdala-derived-EFP biomarker during neurofeedback.
Prism: Supercharging EEG processing with fMRI data
EEG neurofeedback is considered incapable of measuring deep brain regions. Prism is taking a different approach.
Prism’s innovative technology is created in 3 steps:
Step 1
A unique data set of fMRI and EEG
Concurrent EEG and fMRI data was acquired from multiple sessions where the fMRI and EEG were synchronized.
Step 2
Brain area specific EFP (EEG fMRI Pattern)
Using a proprietary model, a unique patient-generic EFP (EEG fMRI pattern) biomarker was created from the synchronized fMRI-EEG data.
Step 3
The Prism system
The EFP model was embedded in Prism forming an EEG neurofeedback device (no fMRI needed) used to train patients to regulate the EFP biomarker signal. Therapy includes 15 thirty-minute sessions, conducted twice a week for a period of 8 weeks (about 2 months). Prism is designed to fit at any clinic.
PTSD-first, to be followed by an extensive pipeline
Our first-to-market solution, Prism for PTSD, is a promising software as a medical device for the treatment of PTSD as an adjunct to standard of care. About 250 million people worldwide live with PTSD, yet treatments are lacking and often lead to side effects that may last a lifetime.
Prism for PTSD: An adjunct to standard of care therapy, was validated in a multi-center clinical trial in 5 medical centers in the USA and in Israel. While using Prism, patients learn to downregulate the amygdala-derived-EFP signal and how to control their PTSD symptoms under the supervision of a healthcare provider.
Relevant publications
Prism’s EFP technology has been extensively published in prestigious medical journals, demonstrating significant clinical improvement across multiple indications and no severe side effects, as an adjunct to standard of care.
We are an innovative company that offers real-time treatment by measuring amygdala-derived-EFP biomarkers
GrayMatters is an innovative company that offers real-time treatment by measuring
amygdala-derived-EFP biomarkers
PTSD-first, to be followed by an extensive pipeline
Our first-to-market solution, Prism for PTSD, is a promising software as a medical device for the treatment of PTSD as an adjunct to standard of care. About 250 million people worldwide live with PTSD, yet treatments are lacking and often lead to side effects that may last a lifetime.
Prism for PTSD: An adjunct to standard of care therapy, was validated in a multi-center clinical trial in 5 medical centers in the USA and in Israel. While using Prism, patients learn to downregulate the amygdala-derived-EFP signal and how to control their PTSD symptoms under the supervision of a healthcare provider.
Relevant publications
Prism’s EFP technology has been extensively published in prestigious medical journals, demonstrating significant clinical improvement across multiple indications and no severe side effects, as an adjunct to standard of care.
We are an innovative company that offers real-time treatment by measuring amygdala-derived-EFP biomarkers.
Latest News and Events
Our Team
Our Partners
Our Partners
